Immune-modulatory effects of syncytiotrophoblast extracellular vesicles in pregnancy and preeclampsia
نویسندگان
چکیده
منابع مشابه
Preeclampsia and Extracellular Vesicles
Preeclampsia is a hypertensive pregnancy disorder characterized by development of hypertension and proteinuria after 20 weeks of gestation that remains a leading cause of maternal and neonatal morbidity and mortality. While preeclampsia is believed to result from complex interactions between maternal and placental factors, the proximate pathophysiology of this syndrome remains elusive. Cell-to-...
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The ability to directly monitor the status of the placenta throughout pregnancy would be a major advance in both general and personalized obstetric care, allowing treatments to be tailored to the dynamic changes that can occur in gestation. Syncytiotrophoblast extracellular vesicles (STBEV) are membrane bound vesicles, released from the surface of the placenta directly into the maternal circula...
متن کاملCharacterisation of Syncytiotrophoblast Vesicles in Normal Pregnancy and Pre-Eclampsia: Expression of Flt-1 and Endoglin
BACKGROUND The placental syncytiotrophoblast releases micro and nanovesicles (STBM), into the maternal circulation in normal pregnancy and in increased amounts in pre-eclampsia (PE), which have proinflammatory and antiangiogenic activity and are implicated in PE pathophysiology. Better characterisation of STBM is essential to understand their role in PE. METHODS AND RESULTS STBM prepared by p...
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با وجود شواهد روزافزونی که بیانگر نقش احتمالی ANP در هموستاز طبیعی مایعات بدن است، اما هنوز اهمیت نقش این پیتید در سلامت و بیماری بدرستی مشخص نیست. بر اثر ازدیاد فشار دهلیزی و تعداد انقباضات آن، ANP از میوسیت های دهلیزی ترشح می شود. تزریق مقادیر زیادی از ANP صناعی به انسان و حیوان سبب کاهش فشار سیستمیک دهلیزی و افزایش دفع سدیم و برقراری دیورز می گردد. مطالعات اخیر بر روی تأثیر تزریق ANP صناعی ...
متن کاملIsolation and characterization of Faecalibacterium prausnitzii extracellular vesicles
Introduction: Extracellular vesicles (EVs) contain active biological compounds which play important roles in biological processes. The secretion of EVs is a common phenomenon which occurs in archaea, bacteria and mammalian cells. The secretion of bacterial EVs has been discovered in various species of both Gram-negative and Gram-positive bacteria. Faecalibacterium prausnitzii is one of the comm...
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ژورنال
عنوان ژورنال: Placenta
سال: 2017
ISSN: 0143-4004
DOI: 10.1016/j.placenta.2017.06.004